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We are looking for a Technical R&D Associate Scientist (m/w/d) (LSB) - BS**​**

Background

Every Roche medicine in clinical development or on the market is supported by Pharma Global Technical Operations. With more than 10'000 employees worldwide, this organisation ensures the reliable manufacturing of our products. Within this network, Pharma Technical Development unites over two thousand specialists focused on designing and delivering innovative solutions that enable the development of new therapies. Through strong collaboration, creativity and scientific excellence, the teams contribute daily to providing high-quality medicines that offer hope to patients.

Within this environment, the Synthetic Molecules Technical Development (PTDC) group plays a central role. PTDC covers drug substance, drug product and analytical sciences and works closely with partners across Research and Early Development, other PTD units and Commercial. Its mission includes the technical advancement of Roche’s synthetic molecules portfolio and the production of clinical supplies for studies.

The open position is based in Analytical Research and Development for Synthetic Molecules. This group develops efficient and cost-effective analytical methods using state-of-the-art technologies such as high-performance liquid chromatography, gas and ion chromatography, and mass spectrometry. The overarching objective is to establish robust control strategies that ensure the reliable release of materials for clinical trials and, ultimately, commercial use.

The Ideal Candidate

You have completed a scientific vocational qualification (e.g. apprenticeship) or hold a Bachelor’s or Master’s degree. You bring 3–5 years of industry experience, specifically in analytical development for oligonucleotides. You are proficient with HPLC, MS, and ideally LC-MS, demonstrate a strong quality mindset with meticulous attention to detail, and feel comfortable adapting to innovative tools and agile work practices. Fluent English communication is essential.

General Information

• Start date: 01.02.2026
• Duration: 12 months
• Extension: possible
• Location: Basel
• Barrier-free workplace: no
• Workload: 100%
• Remote work: up to 10%
• Travel: none
• Team size: 10–15
• Department: Development Team 2 (MMDCAF7B)
• Working hours: standard
• Criminal record extract required: no

Tasks & Responsibilities

• Develop, optimise and validate analytical methods for assessing starting materials, intermediates, reaction progress, active substances and dosage forms.
• Independently plan, conduct and document laboratory work while collaborating closely with team members, the analytical project lead and your supervisor, in alignment with GxP and SOP requirements.
• Contribute to end-to-end analytical workflows in cooperation with associate scientists, scientists and cross-functional partners to support efficient operations and continuous improvement.
• Coordinate analytical activities, including sample logistics, for synthetic product development.
• Prepare scientific and technical documents such as analytical procedures, validation reports, user manuals and SOPs.

Must Haves

• A scientific vocational qualification with 3–5 years of pharmaceutical industry experience focused on oligonucleotide analytics, OR a Bachelor’s/Master’s degree in Analytical Chemistry, Biochemistry, Biotechnology or a related field.
• Practical expertise in analytical techniques (HPLC, MS).
• Experience with LC-MS is a strong advantage.
• Strong interest or background in analytical method development for oligonucleotides.
• Excellent digital skills and an innovative mindset.
• High willingness to learn, improve and adopt new technologies and workflows in a dynamic environment.
• Self-driven, open-minded, reliable, proactive, goal-oriented and a strong team collaborator.
• Openness towards flexible and agile working models.
• Very good English skills; German is beneficial.
• Strong quality awareness and precise working style.
• Confident application of GxP principles appropriate to different clinical phases.

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